Gelucire 5013 Structure

Self-emulsifies in aqueous fluid.

Gelucire 5013 structure. Its hydrophilic property and low melting point makes it a good choice for use as carrier in preparation of solid dispersions by fusion method (Eloy et al., 12). It melts at approximately 50°C and has hydrophilic-lipophilic balance (HLB) value of 13 6, 7. Gelucire ® 50/13 It is a non-ionic, water dispersible surfactant composed of well-characterized PEG-esters, a small glyceride fraction and free PEG.

You can also browse global suppliers,vendor,prices,Price,manufacturers of Gelucire 50-13(-05-8). Visit ChemicalBook To find more Gelucire 50-13(-05-8) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. The results of.

A polyglycolised glyceride lipid carrier, Gelucire 50/13 (G50/13) was used to develop sustained release capsules while high viscosity grade HPMC was used to form sustained release tablets of. Gelucires containing only polyethylene glycol (PEG) esters (Gelucire 55/18) are generally used in the preparation of fast-release formulations, while Gelucires containing only glycerides or a mixture of glycerides and PEG esters (Gelucire 54/02, 50/13, 43/01) are used in the preparation of sustained-release formulations (17,18). Gelucire 50/13 is a mixture of mono-, di-, and triglycerides and mono-, diacyl polyethylene glycols.

A solid dispersion of Meloxicam (MX), a poorly soluble, non steroidal anti-inflammatory drug, and Gelucire 50/13 was prepared by spray drying. Gelucire ® 50/13 structure is mainly imposed by. Amin, Shalam Mohamed Hussain.

The purpose of this research was to develop and optimize a controlled-release multiunit floating system of a highly water soluble drug, ranitidine HCl, using Compritol, Gelucire 50/13, and Gelucire 43/01 as lipid carriers. 12 In a previous work, it was investigated the use of Gelucire 39/01 as a controlled release agent, in combination with the hydrophilic gelling polymer hydroxypropyl methylcellulose (HPMC K15M) and with sodium cross-linked carboximethylcellulose (Carmacel). The dissolution of poorly water soluble drugs may be significantly enhanced in a solid dispersion with hydrophilic lipid excipients, such as Gelucire 50/13 (85), Gelucire 44/14 (,93) compared to.

4), diffractograms of physical mixtures are simply the sum of those of pure components in all cases while the intensity of the peaks of IND diminished with the increase in polymer ratio in case of SDs. Gelucire series of lipids from Gattefossé) are PEG containing mixtures of acylglycerides:. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).

The present paper reports on physical and thermal properties of polyoxyethylene glycol glycerides (Gelucire 50/13) used as sustained release matrix forming agent in pharmaceutical applications. The bioavailability of another HIV protease inhibitor, ritonavir, was also substantially enhanced, relative to a conventional formulation, by using a solid dispersion formulation prepared from a mixture of Gelucire 50/13, polysorbate 80 and polyoxyl 35 castor oil (32). Gelucire containing only glycerides or a mixture of glycerides and PEG esters (Gelucire 39/01, 43/01) are used in the preparation of sustained release formulation.

Gelucire 50/13 (G50/13) was assessed to develop controlled release formulation of salbutamol sulphate (SBL) a highly water soluble drug by semisolid matrix filling capsule technique. How to say Gelucire in English?. Spherical microparticles were yielded with smooth surfaces as observed by scanning electron microscopy.

The cubic mesophases do not melt until the temperature exceeds 40 degrees C. Structure of the final systems and there is a limited understanding of how drug-carrier physical states influence the overall performance of Gelucires-based dispersions produced by spray congealing. Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for GELUCIRE 50-13 (CAS No.

(Gelucirefi 50/13 and Gelucire. 0 relevant articles (0 outcomes, 0 trials/studies) Bio-Agent Context:. The ability of Gelucire 50/13 to yield NLC was evaluated by using Precirol ATO 5 as a model solid lipid and various.

• Vibrational behavior of Gelucire according to the temperature and degree of hydration. Ranitidine HCl-lipid granules. The hydration behavior of this amphiphilic excipient has been investigated.

The Gelucire 50/13 used as sustained release matrix forming agent in pharmaceutical applications and it have demonstrated the ability to improve the dissolution as well as the absorption of poorly. HAVE A LOOK AT OUR NEWEST GELUCIRE ARTICLE HERE. Subscribe to New Research on Gelucire 50-13.

Here you can get chemical information (such as chemical physical properties, safety data, Excellent china suppliers and their web addresses and etc.)by searching the name, CAS number, molecular formula, molecular weight, MDL number, EINECS number, structure. Vibrational behavior of Gelucire in the spectral range 1800–1000 cm −1 at T = 24 °C. Dispersions containing up to 30% w/w drug were prepared and studied using differential scanning calorimetry (DSC), hot.

The dissolution rate of EVR from the optimized SD composed of the drug, Gelucire 50/13 and microcrystalline cellulose in a weight ratio of 1:5:10, was markedly rapid and higher than that from the drug powder and the market product (Afinitor ®, Novartis Pharmaceuticals) in all dissolution mediums tested from pH 3.0 to pH 6.8. • These modes in this spectral range are very sensitive to environmental changes. Worldwide USA China India EMAIL INQUIRY to 9 suppliers.

A strategy to enhance drug release and trypanocidal activity. At last,Gelucire 50-13(-05-8) safety, risk, hazard. Gelucire 50/13 is an excipient composed of fatty acid (C16 and C18) esters of glycerol, PEG esters and free PEG.

Contrary to SD of PEG, the IND peaks remained viewed in higher ratio of polymer (1:4). According to differential scanning calorimetry and powder X-ray diffractometry analysis, MX was. Hydrophilicity and low density, Gelucire 50/13 may be considered an appropriate carrier for designing fast release floating drug delivery system11.

The core is surrounded by surfactants to provide necessary stability. Inert material derived from hydrogenated food-grad oils & fats;. AAPS PharmSciTech Solid dispersion of ursolic acid in Gelucire 50/13:.

Gelucires are defined by their melting point/HLB value. Developed to melt within specific ranges. The solid state characterization using scanning electron microscopy and X-ray powder diffraction, indicated that the drug was homogeneously distributed in the.

ChemicalBook provide Chemical industry users with gelucire 44-14 Boiling point Melting point,gelucire 44-14 Density MSDS Formula Use,If You also need to gelucire 44-14 Other information,welcome to contact us. Josimar de Oliveira Eloy, Juliana Saraiva, Sergio de Albuquerque, Juliana Maldonado Marchetti. GELUCIRE 50-13 (CAS No.

Ethyl cellulose, methylcellulose, and. The effect of incorporating caffeine and paracetamol on the structure and behaviour of Gelucire 50/13 has been studied with a view to establishing whether the choice of drug influences the solid structure and release mechanism. It is able to self-emulsify on contact with aqueous media forming a fine dispersion i.e.

In this work, solid dispersions with Gelucire 50/13 and silicon dioxide, a drying adjuvant, have been generated as an approach to enhance the lipophilic molecule ursolic acid (UA) dissolution profile, for which low bioavailability limits its therapeutic potential. People make our name. In case of IND–Gelu.

The ability of Gelucire 50/13 to nanosize various solid lipids was evaluated. Functionality Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system:.

Curcumin was dissolved in Gelucire 50/13 stearoyl polyethylene glycol (32) glycerides and was stabilized with either Gelucire 50/13 or Pluronic F127. Formulations containing Gelucire 50/13 and Compritol 8 alone failed to float. At body temperature, all crystals in Gelucire 44/14 melt to an isotropic fluid as soon as the total water content exceeds 5%.

USD $ 0.0-0.0/ 1.Our services：A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. Gelucire 50/13 is a semisolid excipient with an HLB value of 13 and melting point of 500C. Laboratory of Condensed Matter Physics, Abdelmalek Essaâdi University, Tetouan, Morocco.

Scanning electron microscopy analysis showed that it was possible to obtain spherically shaped and nonaggregated microparticles;. The PEG and PEG esters presenting a solid phase. Physical characterization As Gelucire® 44/14 is a semi-solid crystalline excipient, formulators should characterize the structure of the mixture containing this lipid-basedvehicleand thedrug substanceto ascer-tain that their formulation is in its most stable formand retains itsself-emulsifying properties.

SLNs consist of a solid lipid core matrix where a drug is solubilized. Application Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Matrix for modified release, Multiparticulates;. Gelucire® 50/13 is a stearoyl polyoxyl/macrogol 32 glycerides NF/EP and consists of mono, di- and triglycerides and PEG-32 (MW 1500) mono- and diesters of palmitic (C16) and stearic (C18) acids.

Gelucire 50/13 was essentially studied by Raman and IR spectroscopies according to the temperature and the degree of hydration. Jammula S et al. Gelucire® 50/13 (stearoyl polyoxyl-32 glycerides) is a nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs.

Solid dispersion (SD) system of everolimus (EVR) with Gelucire 50/13 (Stearoyl polyoxyl-32 glycerides) was prepared using melt granulation technique with the aim of improving the physicochemical properties and dissolution rate. The study describes the application of a spray‐congealing technique, using a new ultrasound‐assisted atomizer to prepare microparticles of diclofenac/Gelucire 50/13, with the aim to obtain a formulation of enhanced‐release, at 10% w/w drug‐to‐excipient ratio, without any employ of solvent. For glycerides mixture (approximately % in weight of the sample), the predominant fatty acid chains is the palmitostearic acid (C16 and C18), with approximately the same proportion of mono-, di- and triglycerides.

The purpose of this research was to develop and optimize a controlled-release multiunit floating system of a highly water soluble drug, ranitidine HCl, using Compritol, Gelucire 50/13, and Gelucire 43/01 as lipid carriers. 13studied the effect of Gelucire 50/13 on disso-. Transition at 36°C to its most stable form.

Present study, the in vitro dissolution showed. ChemicalBook provide Chemical industry users with Gelucire 50-13 Boiling point Melting point,Gelucire 50-13 Density MSDS Formula Use,If You also need to Gelucire 50-13 Other information,welcome to contact us. Purpose.To evaluate the ability of Gelucire 50/13 (an amphiphilic lipid excipient) to act as a stabilizer for lipid nanocarriers such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) and to establish the ability of Gelucire 50/13 based lipid nanocarriers to improve oral delivery of hydrophobic drugs using repaglinide (RPG) as a model drug.

• For the first time, we have assigned all vibrational modes of the Gelucire 50/13. Pronunciation of Gelucire with 2 audio pronunciations and more for Gelucire. The presence of.

Enhancement of dissolution and in vivo evaluation of lornoxicam ternary system with Gelucire 50/13 and polysorbate 80. Its chemical name is Stearoyl macrogol-32 glycerides. It is available in pellet form.

The vibrational behavior of the mixture quercetin/Gelucire 50/13 at room and body temperature. R=C16 or C18 Schematic structures PEG1500 esters O H R -C O -O 3 3 O -C O -R R -C O -O 3 3 Phospholipon® 90G Phospholipon® 90G was received as a gift sample from Phospholipid GmbH (Nattermannalle, Germany). Structure of the main compounds.

Drug,gelucire 50/13 and microcrystalline cellulose in aweight ratio of 1:5:10, was markedly rapid and higher than that from the drug powder and the market product (Afinitor®, Novartis Pharmaceuti-cals) in all dissolution mediums tested from pH 3.0 to pH 6.8. In this work, the utilization of a spray‐congealing technique using a new ultrasonic atomizer to prepare enhanced‐release, solvent‐free microspheres of carbamazepine (CBZ)–Gelucire 50/13 in different drug‐to‐polymer ratios was considered. Gelucire 44/14 forms a lamellar phase and this phase melts at 30 degrees C whereas the pure PEG esters form hexagonal and cubic mesophases.

Ranitidine HCl-lipid granules were prepared by the melt granulation technique and evaluated for in vitro floating and drug release. Lauryl macrogol-32 glycerides (Gelucire 44/14) or stearoyl macrogol-32 glycerides (Gelucire 50/13). Chemicalbook is a platform dedicated to provide the most valuable resources for chemical industry users.

Main components of Gelucire® 50/13. Drug release profiles of SBL release by using G50/13 and its blends with other hydrophilic or hydrophobic materials were investigated.